Synthetic immunomodulation with a CRISPR super-repressor in vivo
Synthetic immunomodulation with a CRISPR super-repressor in vivo
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Transient modulation of the genes involved in immunity, without exerting a permanent change in the DNA code, can be an effective strategy to modulate the course of many inflammatory conditions. CRISPR-Cas9 technology represents a promising platform for achieving this goal. Truncation of guide RNA (gRNA) from the 5′ end enables the application of a...
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Full title
Synthetic immunomodulation with a CRISPR super-repressor in vivo
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7480217
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7480217
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-020-0563-3
