Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2...
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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SETD2 catalyzes methylation at lysine 36 of histone H3 and it has many disease connections. We investigated the substrate sequence specificity of SETD2 and identified nine additional peptide and one protein (FBN1) substrates. Our data showed that SETD2 strongly prefers amino acids different from those in the H3K36 sequence at several positions of i...
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Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7495481
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7495481
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-020-01223-6
