Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in adva...
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
About this item
Full title
Author / Creator
Braun, David A. , Hou, Yue , Bakouny, Ziad , Ficial, Miriam , Sant’ Angelo, Miriam , Forman, Juliet , Ross-Macdonald, Petra , Berger, Ashton C. , Jegede, Opeyemi A. , Elagina, Liudmilla , Steinharter, John , Sun, Maxine , Wind-Rotolo, Megan , Pignon, Jean-Christophe , Cherniack, Andrew D. , Lichtenstein, Lee , Neuberg, Donna , Catalano, Paul , Freeman, Gordon J. , Sharpe, Arlene H. , McDermott, David F. , Van Allen, Eliezer M. , Signoretti, Sabina , Wu, Catherine J. , Shukla, Sachet A. and Choueiri, Toni K.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment with PD-1 blockade by whole-exome and RNA sequencing,...
Alternative Titles
Full title
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
Authors, Artists and Contributors
Author / Creator
Hou, Yue
Bakouny, Ziad
Ficial, Miriam
Sant’ Angelo, Miriam
Forman, Juliet
Ross-Macdonald, Petra
Berger, Ashton C.
Jegede, Opeyemi A.
Elagina, Liudmilla
Steinharter, John
Sun, Maxine
Wind-Rotolo, Megan
Pignon, Jean-Christophe
Cherniack, Andrew D.
Lichtenstein, Lee
Neuberg, Donna
Catalano, Paul
Freeman, Gordon J.
Sharpe, Arlene H.
McDermott, David F.
Van Allen, Eliezer M.
Signoretti, Sabina
Wu, Catherine J.
Shukla, Sachet A.
Choueiri, Toni K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7499153
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7499153
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-020-0839-y
