TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus
1
. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs.
2
,
3
). When PLK4 is chemically inhibited, cell division proceeds without centrosome dupli...
Alternative Titles
Full title
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7501188
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7501188
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2710-1
