Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Thalidomide exerts its teratogenic and immunomodulatory effects by binding to cereblon (CRBN) and thereby inhibiting/modifying the CRBN-mediated ubiquitination pathway consisting of the Cullin4-DDB1-ROC1 E3 ligase complex. The mechanism of thalidomide’s classical hypnotic effect remains largely unexplored, however. Here we examined whether CRBN is...
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Full title
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7502749
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7502749
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1917701117
