Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20
Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20
About this item
Full title
Author / Creator
Schwartz, Daniella Muallem , Blackstone, Sarah A , Sampaio-Moura, Natalia , Rosenzweig, Sofia , Burma, Aarohan M , Stone, Deborah , Hoffmann, Patrycja , Jones, Anne , Romeo, Tina , Barron, Karyl S , Waldman, Meryl A , Aksentijevich, Ivona , Kastner, Daniel L , Milner, Joshua D and Ombrello, Amanda K
Publisher
England: Elsevier Limited
Journal title
Language
English
Formats
Publication information
Publisher
England: Elsevier Limited
Subjects
More information
Scope and Contents
Contents
Mild cases are treated with disease-modifying antirheumatic drugs, whereas severe cases are treated with systemic corticosteroids and biological agents, including tumour necrosis factor (TNF)-α and IL-1 receptor (IL-1R) blockade.1 2 We report that a type I interferon (IFN) signature, or elevation of IFN-stimulated genes (ISGs), correlates with dise...
Alternative Titles
Full title
Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7507120
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7507120
Other Identifiers
ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2019-215918
