HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
About this item
Full title
Author / Creator
Ren, Shuling , Gaykalova, Daria A. , Guo, Theresa , Favorov, Alexander V. , Fertig, Elana J. , Tamayo, Pablo , Callejas-Valera, Juan Luis , Allevato, Mike , Gilardi, Mara , Santos, Jessica , Fukusumi, Takahito , Sakai, Akihiro , Ando, Mizuo , Sadat, Sayed , Liu, Chao , Xu, Guorong , Fisch, Kathleen M. , Wang, Zhiyong , Molinolo, Alfredo A. , Gutkind, J. Silvio , Ideker, Trey , Koch, Wayne M. and Califano, Joseph A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2...
Alternative Titles
Full title
HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
Authors, Artists and Contributors
Author / Creator
Gaykalova, Daria A.
Guo, Theresa
Favorov, Alexander V.
Fertig, Elana J.
Tamayo, Pablo
Callejas-Valera, Juan Luis
Allevato, Mike
Gilardi, Mara
Santos, Jessica
Fukusumi, Takahito
Sakai, Akihiro
Ando, Mizuo
Sadat, Sayed
Liu, Chao
Xu, Guorong
Fisch, Kathleen M.
Wang, Zhiyong
Molinolo, Alfredo A.
Gutkind, J. Silvio
Ideker, Trey
Koch, Wayne M.
Califano, Joseph A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529583
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529583
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-01431-8
