Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify histones and other substrates through the addition of mono- and poly(ADP-ribose) (PAR)
1
–
5
. In the DNA damage responses, this post-translational modification occurs predominantly on serine residues
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–
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and requires HPF1, an accessory facto...
Alternative Titles
Full title
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
Authors, Artists and Contributors
Author / Creator
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529888
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2725-7
