Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised...
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Aims/hypothesis
Aggregation of the beta cell secretory product human islet amyloid polypeptide (hIAPP) results in islet amyloid deposition, a pathological feature of type 2 diabetes. Amyloid formation is associated with increased levels of islet IL-1β as well as beta cell dysfunction and death, but the mechanisms that promote amyloid deposition...
Alternative Titles
Full title
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7529980
Other Identifiers
ISSN
0012-186X,1432-0428
E-ISSN
1432-0428
DOI
10.1007/s00125-020-05232-2
