A computational guided, functional validation of a novel therapeutic antibody proposes Notch signali...
A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma
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Author / Creator
Herrera-Rios, Dayana , Li, Guanzhang , Khan, Dilaware , Tsiampali, Julia , Nickel, Ann-Christin , Aretz, Philippe , Hewera, Michael , Suwala, Abiagail Kora , Jiang, Tao , Steiger, Hans-Jakob , Kamp, Marcel Alexander , Muhammad, Sajjad , Hänggi, Daniel , Maciaczyk, Jarek , Zhang, Wei and Kahlert, Ulf Dietrich
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The Notch signaling network determines stemness in various tissues and targeting signaling activity in malignant brain cancers by gamma-secretase inhibitors (GSI) has shown promising preclinical success. However, the clinical translation remains challenging due to severe toxicity side effects and emergence of therapy resistance. Better anti-Notch d...
Alternative Titles
Full title
A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7531005
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7531005
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-72480-y
