Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus...
Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Microglia are considered both pathogenic and protective during recovery from demyelination, but their precise role remains ill defined. Here, using an inhibitor of colony stimulating factor 1 receptor (CSF1R), PLX5622, and mice infected with a neurotropic coronavirus (mouse hepatitis virus [MHV], strain JHMV), we show that depletion of microglia du...
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Full title
Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7533697
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7533697
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2007814117
