Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation...
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
About this item
Full title
Author / Creator
McWilliam, Hamish E. G. , Mak, Jeffrey Y. W. , Awad, Wael , Zorkau, Matthew , Cruz-Gomez, Sebastian , Lim, Hui Jing , Yan, Yuting , Wormald, Sam , Dagley, Laura F. , Eckle, Sidonia B. G. , Corbett, Alexandra J. , Liu, Haiyin , Li, Shihan , Reddiex, Scott J. J. , Mintern, Justine D. , Liu, Ligong , McCluskey, James , Rossjohn, Jamie , Fairlie, David P. and Villadangos, Jose A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2 synthesis to activate mucosal-associated invariant T (MAIT) cells. Key aspects of this evolutionarily conserved pathway remain uncharacterized, including where MR1 acquires ligands and what accessory proteins assist lig...
Alternative Titles
Full title
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens
Authors, Artists and Contributors
Author / Creator
Mak, Jeffrey Y. W.
Awad, Wael
Zorkau, Matthew
Cruz-Gomez, Sebastian
Lim, Hui Jing
Yan, Yuting
Wormald, Sam
Dagley, Laura F.
Eckle, Sidonia B. G.
Corbett, Alexandra J.
Liu, Haiyin
Li, Shihan
Reddiex, Scott J. J.
Mintern, Justine D.
Liu, Ligong
McCluskey, James
Rossjohn, Jamie
Fairlie, David P.
Villadangos, Jose A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7547156
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7547156
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2011260117
