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Structural basis for selectivity in a highly reducing type II polyketide synthase

Structural basis for selectivity in a highly reducing type II polyketide synthase

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7556716

Structural basis for selectivity in a highly reducing type II polyketide synthase

About this item

Full title

Structural basis for selectivity in a highly reducing type II polyketide synthase

Publisher

New York: Nature Publishing Group US

Journal title

Nature chemical biology, 2020-07, Vol.16 (7), p.776-782

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

Subjects

Subjects and topics

More information

Scope and Contents

Contents

In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF) complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly reducing type II PKSs, represented by IgaPKS, produce polyene structures instead of the well-known aromatic skeletons. Here, we report the crystal structures of the Iga11–Iga...

Alternative Titles

Full title

Structural basis for selectivity in a highly reducing type II polyketide synthase

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7556716

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7556716

Other Identifiers

ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/s41589-020-0530-0

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