Structural basis for selectivity in a highly reducing type II polyketide synthase
Structural basis for selectivity in a highly reducing type II polyketide synthase
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF) complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly reducing type II PKSs, represented by IgaPKS, produce polyene structures instead of the well-known aromatic skeletons. Here, we report the crystal structures of the Iga11–Iga...
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Structural basis for selectivity in a highly reducing type II polyketide synthase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7556716
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7556716
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1552-4450
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1552-4469
DOI
10.1038/s41589-020-0530-0