Senolytic CAR T cells reverse senescence-associated pathologies
Senolytic CAR T cells reverse senescence-associated pathologies
About this item
Full title
Author / Creator
Amor, Corina , Feucht, Judith , Leibold, Josef , Ho, Yu-Jui , Zhu, Changyu , Alonso-Curbelo, Direna , Mansilla-Soto, Jorge , Boyer, Jacob A. , Li, Xiang , Giavridis, Theodoros , Kulick, Amanda , Houlihan, Shauna , Peerschke, Ellinor , Friedman, Scott L. , Ponomarev, Vladimir , Piersigilli, Alessandra , Sadelain, Michel and Lowe, Scott W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment
1
,
2
. Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant cells
3
,
4
and has a beneficial role in wound-healing responses
5
...
Alternative Titles
Full title
Senolytic CAR T cells reverse senescence-associated pathologies
Authors, Artists and Contributors
Author / Creator
Feucht, Judith
Leibold, Josef
Ho, Yu-Jui
Zhu, Changyu
Alonso-Curbelo, Direna
Mansilla-Soto, Jorge
Boyer, Jacob A.
Li, Xiang
Giavridis, Theodoros
Kulick, Amanda
Houlihan, Shauna
Peerschke, Ellinor
Friedman, Scott L.
Ponomarev, Vladimir
Piersigilli, Alessandra
Sadelain, Michel
Lowe, Scott W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7583560
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7583560
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2403-9
