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mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7598064

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

About this item

Full title

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2020-11, Vol.130 (11), p.5976-5988

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

BACKGROUNDTherapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are present in most cancers and offer a specific and hi...

Alternative Titles

Full title

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7598064

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7598064

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI134915

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