Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies
Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer’s disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the present study, the potential of sulforaphane, an isothiocyanate found in cruciferous vegetables, as a BACE1 inh...
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Full title
Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7601397
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7601397
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ISSN
2072-6643
E-ISSN
2072-6643
DOI
10.3390/nu12103026
