Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy
Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Autologous gene therapy using lentiviral vectors (LVs) holds promise for treating monogenetic blood diseases. However, clinical applications can be limited by suboptimal hematopoietic stem cell (HSC) transduction and insufficient quantities of available vector. We recently reported gene therapy for X-linked severe combined immunodeficiency using a...
Alternative Titles
Full title
Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7606410
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7606410
Other Identifiers
ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/s41434-020-0150-z
