Response to trametinib treatment in progressive pediatric low-grade glioma patients
Response to trametinib treatment in progressive pediatric low-grade glioma patients
About this item
Full title
Author / Creator
Selt, Florian , van Tilburg, Cornelis M. , Bison, Brigitte , Sievers, Philipp , Harting, Inga , Ecker, Jonas , Pajtler, Kristian W. , Sahm, Felix , Bahr, Annabelle , Simon, Michèle , Jones, David T. W. , Well, Lennart , Mautner, Victor-Felix , Capper, David , Hernáiz Driever, Pablo , Gnekow, Astrid , Pfister, Stefan M. , Witt, Olaf and Milde, Till
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
Subjects
More information
Scope and Contents
Contents
Introduction
A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling of the mitogen activated protein kinase (MAPK) pathway. Hence, inhibition of MAPK signaling using small molecule inhibitors such as MEK inhibitors (MEKi) may be a promising strategy.
Methods
In this multi-center retrospective centrally reviewed study, we ana...
Alternative Titles
Full title
Response to trametinib treatment in progressive pediatric low-grade glioma patients
Authors, Artists and Contributors
Author / Creator
van Tilburg, Cornelis M.
Bison, Brigitte
Sievers, Philipp
Harting, Inga
Ecker, Jonas
Pajtler, Kristian W.
Sahm, Felix
Bahr, Annabelle
Simon, Michèle
Jones, David T. W.
Well, Lennart
Mautner, Victor-Felix
Capper, David
Hernáiz Driever, Pablo
Gnekow, Astrid
Pfister, Stefan M.
Witt, Olaf
Milde, Till
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7609413
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7609413
Other Identifiers
ISSN
0167-594X
E-ISSN
1573-7373
DOI
10.1007/s11060-020-03640-3
