A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
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Author / Creator
Napolitano, Gennaro , Di Malta, Chiara , Esposito, Alessandra , de Araujo, Mariana E. G. , Pece, Salvatore , Bertalot, Giovanni , Matarese, Maria , Benedetti, Valerio , Zampelli, Angela , Stasyk, Taras , Siciliano, Diletta , Venuta, Alessandro , Cesana, Marcella , Vilardo, Claudia , Nusco, Edoardo , Monfregola, Jlenia , Calcagnì, Alessia , Di Fiore, Pier Paolo , Huber, Lukas A. and Ballabio, Andrea
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates
1
–
3
. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we sho...
Alternative Titles
Full title
A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
Authors, Artists and Contributors
Author / Creator
Di Malta, Chiara
Esposito, Alessandra
de Araujo, Mariana E. G.
Pece, Salvatore
Bertalot, Giovanni
Matarese, Maria
Benedetti, Valerio
Zampelli, Angela
Stasyk, Taras
Siciliano, Diletta
Venuta, Alessandro
Cesana, Marcella
Vilardo, Claudia
Nusco, Edoardo
Monfregola, Jlenia
Calcagnì, Alessia
Di Fiore, Pier Paolo
Huber, Lukas A.
Ballabio, Andrea
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610377
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610377
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2444-0
