Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
About this item
Full title
Author / Creator
Edner, Natalie M. , Heuts, Frank , Thomas, Niclas , Wang, Chun Jing , Petersone, Lina , Kenefeck, Rupert , Kogimtzis, Alexandros , Ovcinnikovs, Vitalijs , Ross, Ellen M. , Ntavli, Elisavet , Elfaki, Yassin , Eichmann, Martin , Baptista, Roman , Ambery, Philip , Jermutus, Lutz , Peakman, Mark , Rosenthal, Miranda and Walker, Lucy S. K.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Follicular helper T (T
FH
) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether T
FH
cells were decreased by costimulation blockade using the CTLA-4–immunoglobulin (Ig) fusion protein (abatacept) in a mouse model of diabetes and in individuals with new-onset T1D....
Alternative Titles
Full title
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
Authors, Artists and Contributors
Author / Creator
Heuts, Frank
Thomas, Niclas
Wang, Chun Jing
Petersone, Lina
Kenefeck, Rupert
Kogimtzis, Alexandros
Ovcinnikovs, Vitalijs
Ross, Ellen M.
Ntavli, Elisavet
Elfaki, Yassin
Eichmann, Martin
Baptista, Roman
Ambery, Philip
Jermutus, Lutz
Peakman, Mark
Rosenthal, Miranda
Walker, Lucy S. K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610476
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7610476
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-0744-z
