Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
About this item
Full title
Author / Creator
Braga, Luca , Ali, Hashim , Secco, Ilaria , Chiavacci, Elena , Neves, Guilherme , Goldhill, Daniel , Penn, Rebecca , Jimenez-Guardeño, Jose M. , Ortega-Prieto, Ana M. , Bussani, Rossana , Cannatà, Antonio , Rizzari, Giorgia , Collesi, Chiara , Schneider, Edoardo , Arosio, Daniele , Shah, Ajay M. , Barclay, Wendy S. , Malim, Michael H. , Burrone, Juan and Giacca, Mauro
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
COVID-19 is a disease with unique characteristics that include lung thrombosis
1
, frequent diarrhoea
2
, abnormal activation of the inflammatory response
3
and rapid deterioration of lung function consistent with alveolar oedema
4
. The pathological substrate for these findings remains unknown. Here we show that the lungs o...
Alternative Titles
Full title
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Authors, Artists and Contributors
Author / Creator
Ali, Hashim
Secco, Ilaria
Chiavacci, Elena
Neves, Guilherme
Goldhill, Daniel
Penn, Rebecca
Jimenez-Guardeño, Jose M.
Ortega-Prieto, Ana M.
Bussani, Rossana
Cannatà, Antonio
Rizzari, Giorgia
Collesi, Chiara
Schneider, Edoardo
Arosio, Daniele
Shah, Ajay M.
Barclay, Wendy S.
Malim, Michael H.
Burrone, Juan
Giacca, Mauro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611055
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611055
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03491-6
