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Inherent mosaicism and extensive mutation of human placentas

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Inherent mosaicism and extensive mutation of human placentas

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611644

Inherent mosaicism and extensive mutation of human placentas

About this item

Full title

Inherent mosaicism and extensive mutation of human placentas

Author / Creator

Coorens, Tim H. H. , Oliver, Thomas R. W. , Sanghvi, Rashesh , Sovio, Ulla , Cook, Emma , Vento-Tormo, Roser , Haniffa, Muzlifah , Young, Matthew D. , Rahbari, Raheleh , Sebire, Neil , Campbell, Peter J. , Charnock-Jones, D. Stephen , Smith, Gordon C. S. and Behjati, Sam

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2021-04, Vol.592 (7852), p.80-85

Language

English

Formats

Articles

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

More information

Scope and Contents

Contents

Placentas can exhibit chromosomal aberrations that are absent from the fetus
1
. The basis of this genetic segregation, which is known as confined placental mosaicism, remains unknown. Here we investigated the phylogeny of human placental cells as reconstructed from somatic mutations, using whole-genome sequencing of 86 bulk placental samples...

Alternative Titles

Full title

Inherent mosaicism and extensive mutation of human placentas

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611644

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7611644

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-021-03345-1

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