Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 e...
Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway
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Publisher
Greece: Spandidos Publications
Journal title
Language
English
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Publisher
Greece: Spandidos Publications
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Scope and Contents
Contents
Tissue damage in diabetes is at least partly due to elevated reactive oxygen species production by the mitochondrial respiratory chain during hyperglycemia. Sustained hyperglycemia results in mitochondrial dysfunction and the abnormal expression of mitochondrial genes, such as NADH: Ubiquinone oxidoreductase subunit A13 (NDUFA13). Metformin, an AMP...
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Full title
Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7646981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7646981
Other Identifiers
ISSN
1791-2997
E-ISSN
1791-3004
DOI
10.3892/mmr.2020.11599
