PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, am...
PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
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Author / Creator
Okishio, Shinya , Yamaguchi, Kanji , Ishiba, Hiroshi , Tochiki, Nozomi , Yano, Kota , Takahashi, Aya , Kataoka, Seita , Okuda, Keiichiroh , Seko, Yuya , Liu, Yu , Fujii, Hideki , Takahashi, Daiki , Ito, Yusuke , Kamon, Junji , Umemura, Atsushi , Moriguchi, Michihisa , Yasui, Kohichiroh , Okanoue, Takeshi and Itoh, Yoshito
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mechanisms involved. Mice were fed control chow or a choline-deficient
l
-amino acid-defined diet c...
Alternative Titles
Full title
PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7658250
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7658250
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-75805-z
