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The malaria parasite Plasmodium obligatorily infects and replicates inside hepatocytes surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell derived autophagy protein LC3. We have previously shown that the parasite-derived, PVM-resident protein UIS3 sequesters LC3 to avoid parasite elimination by autop...

Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

10.1038/s42003-020-01422-1