CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
About this item
Full title
Author / Creator
Biasci, Daniele , Smoragiewicz, Martin , Connell, Claire M. , Wang, Zhikai , Gao, Ya , Thaventhiran, James E. D. , Basu, Bristi , Magiera, Lukasz , Johnson, T. Isaac , Bax, Lisa , Gopinathan, Aarthi , Isherwood, Christopher , Gallagher, Ferdia A. , Pawula, Maria , Hudecova, Irena , Gale, Davina , Rosenfeld, Nitzan , Barmpounakis, Petros , Popa, Elizabeta Cristina , Brais, Rebecca , Godfrey, Edmund , Mirk, Fraz , Richards, Frances M. , Fearon, Douglas T. , Janowitz, Tobias and Jodrell, Duncan I.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Inhibition of the chemokine receptor CXCR4 in combination with blockade of the PD-1/PD-L1 T cell checkpoint induces T cell infiltration and anticancer responses in murine and human pancreatic cancer. Here we elucidate the mechanism by which CXCR4 inhibition affects the tumor immune microenvironment. In human immune cell-based chemotaxis assays, we...
Alternative Titles
Full title
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
Authors, Artists and Contributors
Author / Creator
Smoragiewicz, Martin
Connell, Claire M.
Wang, Zhikai
Gao, Ya
Thaventhiran, James E. D.
Basu, Bristi
Magiera, Lukasz
Johnson, T. Isaac
Bax, Lisa
Gopinathan, Aarthi
Isherwood, Christopher
Gallagher, Ferdia A.
Pawula, Maria
Hudecova, Irena
Gale, Davina
Rosenfeld, Nitzan
Barmpounakis, Petros
Popa, Elizabeta Cristina
Brais, Rebecca
Godfrey, Edmund
Mirk, Fraz
Richards, Frances M.
Fearon, Douglas T.
Janowitz, Tobias
Jodrell, Duncan I.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7682333
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7682333
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2013644117
