Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
De novo formation of the double-membrane compartment autophagosome is seeded by small vesicles carrying membrane protein autophagy-related 9 (ATG9), the function of which remains unknown. Here we find that ATG9A scrambles phospholipids of membranes in vitro. Cryo-EM structures of human ATG9A reveal a trimer with a solvated central pore, which is co...
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Full title
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7718406
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7718406
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-00520-2
