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Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7720237

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

About this item

Full title

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (48), p.30649-30660

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Myasthenia gravis (MG) is a neuromuscular, autoimmune disease caused by autoantibodies that target postsynaptic proteins, primarily the acetylcholine receptor (AChR) and inhibit signaling at the neuromuscular junction. The majority of patients under 50 y with AChR autoantibody MG have thymic lymphofollicular hyperplasia. The MG thymus is a reservoi...

Alternative Titles

Full title

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7720237

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7720237

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2007206117

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