An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
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Author / Creator
Dussiot, Michael , Maciel, Thiago T , Fricot, Aurélie , Chartier, Céline , Negre, Olivier , Veiga, Joel , Grapton, Damien , Paubelle, Etienne , Payen, Emmanuel , Beuzard, Yves , Leboulch, Philippe , Ribeil, Jean-Antoine , Arlet, Jean-Benoit , Coté, Francine , Courtois, Geneviève , Ginzburg, Yelena Z , Daniel, Thomas O , Chopra, Rajesh , Sung, Victoria , Hermine, Olivier and Moura, Ivan C
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Michael Dussiot
et al
. show that an activin receptor IIA ligand trap ameliorates anemia in a mouse model of β-thalassemia by blocking the deleterious effects of GDF11. Mechanistically, GDF11 inactivation reversed ineffective erythropoiesis by promoting terminal erythroblast differentiation and by inducing apoptosis of immature erythroblasts....
Alternative Titles
Full title
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Authors, Artists and Contributors
Author / Creator
Maciel, Thiago T
Fricot, Aurélie
Chartier, Céline
Negre, Olivier
Veiga, Joel
Grapton, Damien
Paubelle, Etienne
Payen, Emmanuel
Beuzard, Yves
Leboulch, Philippe
Ribeil, Jean-Antoine
Arlet, Jean-Benoit
Coté, Francine
Courtois, Geneviève
Ginzburg, Yelena Z
Daniel, Thomas O
Chopra, Rajesh
Sung, Victoria
Hermine, Olivier
Moura, Ivan C
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7730561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7730561
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.3468
