Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dys...
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
About this item
Full title
Author / Creator
Olonisakin, Tolani F. , Suber, Tomeka , Gonzalez-Ferrer, Shekina , Xiong, Zeyu , Peñaloza, Hernán F. , van der Geest, Rick , Xiong, Yuting , Osei-Hwedieh, David O. , Tejero, Jesús , Rosengart, Matthew R. , Mars, Wendy M. , Van Tyne, Daria , Perlegas, Andreas , Brashears, Samuel , Kim-Shapiro, Daniel B. , Gladwin, Mark T. , Bachman, Michael A. , Hod, Eldad A. , St. Croix, Claudette , Tyurina, Yulia Y. , Kagan, Valerian E. , Mallampalli, Rama K. , Ray, Anuradha , Ray, Prabir and Lee, Janet S.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Macrophages are main effectors of heme metabolism, increasing transiently in the liver during heightened disposal of damaged or senescent RBCs (sRBCs). Macrophages are also essential in defense against microbial threats, but pathological states of heme excess may be immunosuppressive. Herein, we uncovered a mechanism whereby an acute rise in sRBC d...
Alternative Titles
Full title
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
Authors, Artists and Contributors
Author / Creator
Suber, Tomeka
Gonzalez-Ferrer, Shekina
Xiong, Zeyu
Peñaloza, Hernán F.
van der Geest, Rick
Xiong, Yuting
Osei-Hwedieh, David O.
Tejero, Jesús
Rosengart, Matthew R.
Mars, Wendy M.
Van Tyne, Daria
Perlegas, Andreas
Brashears, Samuel
Kim-Shapiro, Daniel B.
Gladwin, Mark T.
Bachman, Michael A.
Hod, Eldad A.
St. Croix, Claudette
Tyurina, Yulia Y.
Kagan, Valerian E.
Mallampalli, Rama K.
Ray, Anuradha
Ray, Prabir
Lee, Janet S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7773401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7773401
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI137468
