A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins
A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique in the field of structural biology. However, the inability to reliably produce pure, homogeneous membrane protein samples hampers the progress of their structural determination. Here, we develop a bottom-up iterative method, Build and Retrieve (BaR), that enables the...
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A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7808410
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7808410
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-020-01021-2
