WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition
About this item
Full title
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Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
United States: Massachusetts Medical Society
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Scope and Contents
Contents
PTEN defects underlie disorders with several heritable neoplasms, including the Cowden syndrome, but many patients with these syndromes do not carry
PTEN
mutations. Some patients with hamartomatous inherited tumors have enhanced function of the WWP1 ubiquitin ligase that increases PTEN degradation and fosters tumor-promoting PI3K activity.
Alternative Titles
Full title
WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7839065
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7839065
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1914919
