Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle tra...
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure. We have previously demonstrated that neutrophil-specific microRNA-223 (miR-223) is elevated in hepatocytes to limit NASH progression in obese mice. Here, we demonstrated that thi...
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Full title
Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7843220
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7843220
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ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI141513
