Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN) is poorly understood. Here, we report that the CIPN-causing drug bortezomib (Bort) promotes delta 2 tubulin (D2) accumulation while affecting microtubule stability and dynamics in sensory neurons in vitro and in vivo and that the accumulation of D2 is predominant in unmyelinated...
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Full title
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7848563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7848563
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2012685118
