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Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine h...

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine h...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853096

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction

About this item

Full title

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction

Publisher

England: Nature Publishing Group

Journal title

Neuropsychopharmacology, 2021-01, Vol.46 (2), p.288-296

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

More information

Scope and Contents

Contents

Cocaine is known to increase brain dopamine at supranormal levels in comparison to alternative nondrug rewards. According to the dopamine hypothesis of addiction, this abnormally large dopamine response would explain why cocaine use is initially highly rewarding and addictive. Though resting on solid neuroscientific foundations, this hypothesis has...

Alternative Titles

Full title

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853096

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853096

Other Identifiers

ISSN

0893-133X

E-ISSN

1740-634X,0007-0920

DOI

10.1038/s41386-020-0786-9

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