Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine h...
Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
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England: Nature Publishing Group
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English
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England: Nature Publishing Group
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Cocaine is known to increase brain dopamine at supranormal levels in comparison to alternative nondrug rewards. According to the dopamine hypothesis of addiction, this abnormally large dopamine response would explain why cocaine use is initially highly rewarding and addictive. Though resting on solid neuroscientific foundations, this hypothesis has...
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Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853096
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853096
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ISSN
0893-133X
E-ISSN
1740-634X,0007-0920
DOI
10.1038/s41386-020-0786-9