CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the...
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ
About this item
Full title
Author / Creator
Chen, Ruo , Wang, Ke , Feng, Zhuan , Zhang, Ming-Yang , Wu, Jiao , Geng, Jie-Jie and Chen, Zhi-Nan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Thymic involution during aging is a major cause of decreased T-cell production and reduced immunity. Here, we show that the loss of CD147 on T cells prevents thymic senescence, resulting in slowed shrinkage of the thymus with age and increased production of naive T cells. This phenotype is the result of slowing of the epithelial–mesenchymal transit...
Alternative Titles
Full title
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853129
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7853129
Other Identifiers
ISSN
1672-7681
E-ISSN
2042-0226
DOI
10.1038/s41423-019-0353-7
