Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairme...
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
About this item
Full title
Author / Creator
Ogrodnik, Mikolaj , Evans, Shane A. , Fielder, Edward , Victorelli, Stella , Kruger, Patrick , Salmonowicz, Hanna , Weigand, Bettina M. , Patel, Ayush D. , Pirtskhalava, Tamar , Inman, Christine L. , Johnson, Kurt O. , Dickinson, Stephanie L. , Rocha, Azucena , Schafer, Marissa J. , Zhu, Yi , Allison, David B. , Zglinicki, Thomas , LeBrasseur, Nathan K. , Tchkonia, Tamar , Neretti, Nicola , Passos, João F. , Kirkland, James L. and Jurk, Diana
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a major contributor to aging and age‐related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it is still u...
Alternative Titles
Full title
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
Authors, Artists and Contributors
Author / Creator
Evans, Shane A.
Fielder, Edward
Victorelli, Stella
Kruger, Patrick
Salmonowicz, Hanna
Weigand, Bettina M.
Patel, Ayush D.
Pirtskhalava, Tamar
Inman, Christine L.
Johnson, Kurt O.
Dickinson, Stephanie L.
Rocha, Azucena
Schafer, Marissa J.
Zhu, Yi
Allison, David B.
Zglinicki, Thomas
LeBrasseur, Nathan K.
Tchkonia, Tamar
Neretti, Nicola
Passos, João F.
Kirkland, James L.
Jurk, Diana
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7884042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7884042
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.13296
