Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
About this item
Full title
Author / Creator
Yuan, Gang , Flores, Natasha M. , Hausmann, Simone , Lofgren, Shane M. , Kharchenko, Vladlena , Angulo-Ibanez, Maria , Sengupta, Deepanwita , Lu, Xiaoyin , Czaban, Iwona , Azhibek, Dulat , Vicent, Silvestre , Fischle, Wolfgang , Jaremko, Mariusz , Fang, Bingliang , Wistuba, Ignacio I. , Chua, Katrin F. , Roth, Jack A. , Minna, John D. , Shao, Ning-Yi , Jaremko, Łukasz , Mazur, Pawel K. and Gozani, Or
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been implicated in the aetiology of lung squamous cell carcinoma (LUSC)
1
–
3
. The
FGFR1
gene is the main candidate driver of tumorigenesis within this region
4
. However, clinical trials evaluating FGFR1 inhibition as a targeted therapy hav...
Alternative Titles
Full title
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Authors, Artists and Contributors
Author / Creator
Flores, Natasha M.
Hausmann, Simone
Lofgren, Shane M.
Kharchenko, Vladlena
Angulo-Ibanez, Maria
Sengupta, Deepanwita
Lu, Xiaoyin
Czaban, Iwona
Azhibek, Dulat
Vicent, Silvestre
Fischle, Wolfgang
Jaremko, Mariusz
Fang, Bingliang
Wistuba, Ignacio I.
Chua, Katrin F.
Roth, Jack A.
Minna, John D.
Shao, Ning-Yi
Jaremko, Łukasz
Mazur, Pawel K.
Gozani, Or
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7895461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7895461
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-03170-y
