β-Adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins
β-Adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
The number and activity of Cav1.2 channels in the cardiomyocyte sarcolemma tunes the magnitude of Ca2+-induced Ca2+ release and myocardial contraction. β-Adrenergic receptor (βAR) activation stimulates sarcolemmal insertion of Cav1.2. This supplements the preexisting sarcolemmal Cav1.2 population, forming large “superclusters” wherein neighboring c...
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Full title
β-Adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7896340
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7896340
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2017937118
