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BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906956

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

About this item

Full title

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

Publisher

New York: Nature Publishing Group US

Journal title

Nature immunology, 2021-03, Vol.22 (3), p.370-380

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

During chronic infection and cancer, a self-renewing CD8
+
T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8
+
T cells diverge from other CD8
+
subsets early after chronic viral infection. However, pathways guarding stem-like CD8
+
T cells against terminal e...

Alternative Titles

Full title

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906956

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906956

Other Identifiers

ISSN

1529-2908

E-ISSN

1529-2916

DOI

10.1038/s41590-021-00868-7

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