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Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I an...

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Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I an...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7923353

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

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Full title

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

Author / Creator

Zhou, Yixuan , Bastian, Ingmar Niels , Long, Mark D. , Dow, Michelle , Li, Weihua , Liu, Tao , Ngu, Rachael Katie , Antonucci, Laura , Huang, Jian Yu , Phung, Qui T. , Zhao, Xi-he , Banerjee, Sourav , Lin, Xue-Jia , Wang, Hongxia , Dang, Brian , Choi, Sylvia , Karin, Daniel , Su, Hua , Ellisman, Mark H. , Jamieson, Christina , Bosenberg, Marcus , Cheng, Zhang , Haybaeck, Johannes , Kenner, Lukas , Fisch, Kathleen M. , Bourgon, Richard , Hernandez, Genevive , Lill, Jennie R. , Liu, Song , Carter, Hannah , Mellman, Ira , Karin, Michael and Shalapour, Shabnam

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8), p.1-12

Language

English

Formats

Articles

Publication information

Publisher

United States: National Academy of Sciences

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Many cancers evade immune rejection by suppressing major histocompatibility class I (MHC-I) antigen processing and presentation (AgPP). Such cancers do not respond to immune checkpoint inhibitor therapies (ICIT) such as PD-1/PD-L1 [PD-(L)1] blockade. Certain chemotherapeutic drugs augment tumor control by PD-(L)1 inhibitors through potentiation of...

Alternative Titles

Full title

Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation

Authors, Artists and Contributors

Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7923353

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7923353

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.2025840118

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