Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Receptor-interacting protein 1 (RIP1; RIPK1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. TNF-TNFR1 triggered signaling complex formation, subsequent NF-κB and MAPK activation and induction of cell death involve RIPK1 ubiquitination at several lysine residues including Lys376 and Lys115. Here...
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Full title
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7937686
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7937686
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-020-00629-3
