Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Functional diversity of the highly polymorphic human leukocyte antigen class I (
HLA
-I) genes underlies successful immunologic control of both infectious disease and cancer. The divergent allele advantage hypothesis dictates that an
HLA
-I genotype with two alleles with sequences that are more divergent enables presentation of more div...
Alternative Titles
Full title
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7938381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7938381
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-019-0639-4
