ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice: Mitoch...
ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice: Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
About this item
Full title
Author / Creator
Cui, Liyang , Gouw, Arvin M. , LaGory, Edward L. , Guo, Shenghao , Attarwala, Nabeel , Tang, Yao , Qi, Ji , Chen, Yun-Sheng , Gao, Zhou , Casey, Kerriann M. , Bazhin, Arkadiy A. , Chen, Min , Hu, Leeann , Xie, Jinghang , Fang, Mingxi , Zhang, Cissy , Zhu, Qihua , Wang, Zhiyuan , Giaccia, Amato J. , Gambhir, Sanjiv Sam , Zhu, Weiping , Felsher, Dean W. , Pegram, Mark D. , Goun, Elena A. , Le, Anne and Rao, Jianghong
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxic or ineffective for clinical application. Here we develop a safe, mitochondria-targeted, copp...
Alternative Titles
Full title
ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice: Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
Authors, Artists and Contributors
Author / Creator
Gouw, Arvin M.
LaGory, Edward L.
Guo, Shenghao
Attarwala, Nabeel
Tang, Yao
Qi, Ji
Chen, Yun-Sheng
Gao, Zhou
Casey, Kerriann M.
Bazhin, Arkadiy A.
Chen, Min
Hu, Leeann
Xie, Jinghang
Fang, Mingxi
Zhang, Cissy
Zhu, Qihua
Wang, Zhiyuan
Giaccia, Amato J.
Gambhir, Sanjiv Sam
Zhu, Weiping
Felsher, Dean W.
Pegram, Mark D.
Goun, Elena A.
Le, Anne
Rao, Jianghong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7956242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7956242
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-020-0707-9
