Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis
Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Blood pH is tightly maintained between 7.35 and 7.45, and acidosis (pH <7.3) indicates poor prognosis in sepsis, wherein lactic acid from anoxic tissues overwhelms the buffering capacity of blood. Poor sepsis prognosis is also associated with low zinc levels and the release of High mobility group box 1 (HMGB1) from activated and/or necrotic cells....
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Full title
Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958265
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958265
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2018090118
