Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast...
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
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Author / Creator
Yang, Peng-bo , Hou, Pei-pei , Liu, Fu-yuan , Hong, Wen-bin , Chen, Hang-zi , Sun, Xiao-yu , Li, Peng , Zhang, Yi , Ju, Cui-yu , Luo, Li-juan , Wu, Sheng-fu , Zhou, Jia-xin , Wang, Zhi-jing , He, Jian-ping , Li, Li , Zhao, Tong-Jin , Deng, Xianming , Lin, Tianwei and Wu, Qiao
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Nuclear receptor Nur77 participates in multiple metabolic regulations and plays paradoxical roles in tumorigeneses. Herein, we demonstrated that the knockout of Nur77 stimulated mammary tumor development in two mouse models, which would be reversed by a specific reexpression of Nur77 in mammary tissues. Mechanistically, Nur77 interacted and recruit...
Alternative Titles
Full title
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7959534
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7959534
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2002997117
