17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension v...
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin
About this item
Full title
Author / Creator
Frump, Andrea L. , Albrecht, Marjorie , Yakubov, Bakhtiyor , Breuils-Bonnet, Sandra , Nadeau, Valérie , Tremblay, Eve , Potus, Francois , Omura, Junichi , Cook, Todd , Fisher, Amanda , Rodriguez, Brooke , Brown, R. Dale , Stenmark, Kurt R. , Rubinstein, C. Dustin , Krentz, Kathy , Tabima, Diana M. , Li, Rongbo , Sun, Xin , Chesler, Naomi C. , Provencher, Steeve , Bonnet, Sebastien and Lahm, Tim
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating the procontractile and prosurvival peptide apelin...
Alternative Titles
Full title
17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin
Authors, Artists and Contributors
Author / Creator
Albrecht, Marjorie
Yakubov, Bakhtiyor
Breuils-Bonnet, Sandra
Nadeau, Valérie
Tremblay, Eve
Potus, Francois
Omura, Junichi
Cook, Todd
Fisher, Amanda
Rodriguez, Brooke
Brown, R. Dale
Stenmark, Kurt R.
Rubinstein, C. Dustin
Krentz, Kathy
Tabima, Diana M.
Li, Rongbo
Sun, Xin
Chesler, Naomi C.
Provencher, Steeve
Bonnet, Sebastien
Lahm, Tim
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7968046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7968046
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI129433
