Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Cholesterol serves critical roles in enveloped virus fusion by modulating membrane properties. The glycoprotein (GP) of Ebola virus (EBOV) promotes fusion in the endosome, a process that requires the endosomal cholesterol transporter NPC1. However, the role of cholesterol in EBOV fusion is unclear. Here we show that cholesterol in GP-containing mem...
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Full title
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7992113
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7992113
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-00548-4
