ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications...
ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP
About this item
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Author / Creator
Han, Jinhua , Wan, Li , Jiang, Guixing , Cao, Liping , Xia, Feiyu , Tian, Tian , Zhu, Xiaomei , Wu, Mingjie , Huen, Michael S. Y. , Wang, Yi , Liu, Ting and Huang, Jun
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
DNA end resection is a critical step in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). However, the mechanisms governing the extent of resection at DSB sites undergoing homology-directed repair remain unclear. Here, we show that, upon DSB induction, the key resection factor CtIP is modified by the ubiquitin-like pr...
Alternative Titles
Full title
ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8000100
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8000100
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2022600118
