Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblast...
Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a co...
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Full title
Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8011892
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8011892
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI142580
